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Abstract 1,2,4-Triazole represents an important class of heterocyclic unit found to have wide range of applications in chemistry and biology.83 Particularly, heterocycle fused-triazoles received a long standing interest due to their medicinal relevance. [1,2,4]Triazolo[4,3-a]pyridine, a hybrid 1,2,4-triazole and pyridine, is an important prototype of this family, and one of the well studied systems of this kind in literature. This motif embedded compounds are found to display biological activities such as antibacterial, antifungal, anti-inflammatory, antiproliferative, antithrombotic, anticonvulsant, herbicidal, and anxiolytic activity. Like triazolopyridines, triazolopyridazines, and the diazine congeners, triazolopyrimidines as well as triazoloquinolines are other important frameworks that belong to heterocycle fused-triazoles wherein 1,2,4- triazole is fused with pyridazines, pyrimidines, and quinolines, respectively. Owing to their broad spectrum of biological activities, heterocycle fused-triazoles have gained considerable interest among the researchers and these systems can be routinely synthesized by constructing the 1,2,4-triazole motif by adopting either dehydrative cyclization of acyl hydrazides or oxidative cyclization of heteroaryl hydrazones. Although the former method was used successfully for the efficient preparation of numerous heterocyclic compounds, the latter is the most common, attractive and widely exploited method. |