الفهرس 
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Abstract
Salinomycin were studied for its toxicity and silymarin for prophylactic management in male rabbits. Male rabbits were randomly divided into 7 groups with 7 rabbits in each. group 1.2 and 3 were maintained as cotrol group, salinomycin dose (20 mg/kg feed) and salinomycin dose (40 mg/ kg feed ), respectivaly. group 4 was fed on feed contanining salinomycin (20 mg/kg feed) and silymarin (6.5 mg/kg body weight). group 5 received feed contaning salinomycin dose (40 mg/kg feed) and silymarin (13 mg/kg body weight). group 6 and were fed on feed containing silymarin (6.5 and 13 mg/kg body weight), respectively. Duration of the experiment is 28 days. Weekly body weights revealed a significant decrease in 3rd group as compared to group. the activity of Malondialdehyde and the values of aspartate aminotransfese, alanine aminotransferase, total proteins, albumin, total cholesterol, triglycerides, low density lipoproteinine were significantly elevated in 2nd and 3rd group while glutathione,catalase, superoxide dismutase and high density lipoproteins were significantly lowered as compared to control group. thus, it is enunciated that salinomycin toxicity is due to oxidative damage and use of silymarin in feed tends to cure and avoid any accidental toxicity. Relative weight of liver , kidneys, testicle and spleen increased significantly in 3in group. There were mild pathologic changes in organs of 2nd group wherein there were sever pathologic chages at 3rd group when compared with control. feed ) and salinomycin dose