الفهرس | Only 14 pages are availabe for public view |
Abstract Musculoskeletal injures are the most common cause of severe long-term pain, physical disability and accounting for the majority of all sport-related injuries. Moreover, the social cost of these injuries includes lost job wages and production. In competitive or professional athletes, this loss may have extreme consequences. Platelet-rich plasma (PRP) is an autologous concentration of human platelets to supra-physiologic levels. PRP has healing properties that have been attributed to the increased concentrations of autologous tissue growth factors and proteins at cellular level. These factors, when introduced to the area of the injury, are expected to increase recruitment, proliferation and differentiation of cells involved in tissue repair, and to promote accelerated repair with better tissue differentiation. Aim of the work The aim of this work was to evaluate of the role of platelet rich plasma in healing of experimentally induced skeletal muscle injury in adult male albino rats. Materials and Methods: The current study was carried out on 48 adult male albino rats of average weight 200 grams. 179 Summary and Conclusion The animals were divided into three groups: group I (control group): consisted of 24 rats which was subdivided into three subgroups: Subgroup IA (`12 rats): from which blood was collected from retro orbital plexus for platelet rich plasma preparation. Subgroup IB (4 rats): from which the gastrocnemius muscles were obtained from both lower limbs without any maneuvers after 1, 7, 14 and 21 days. Subgroup IC (8 rats): from which the gastrocnemius muscles were obtained from both lower limbs after 1, 7, 14 and 21days of their injection with platelet rich plasma without injury. group II: consisted of 12 rats. In each rat, the hair over the gastrocnemius muscle was shaved, the rat was anesthetized and the muscles of both lower limbs were injured and left without treatment. This group was subdivided into four equal subgroups: Subgroup IIA (3 rats): In which the muscle specimens were obtained at day 1 after injury. Subgroup IIB (3 rats): In which the muscle specimens were obtained at day 7 after injury. Subgroup IIC (3 rats): In which the muscle specimens were obtained at day 14 after injury. Subgroup IID (3 rats): In which the muscle specimens were obtained at day 21 after injury |