الفهرس 
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Abstract
Although OA is generally assessed using standard radiographic images in clinical practice, biochemical markers can be used to detect disease and determine its severity. Presence of adiponectin is well correlated with various inflammatory diseases. We examined whether serum adiponectin are also associated with primary knee O.A severity.
We conducted our study on 30 O.A patients and 10 normal healthy subjects serving as a control group. All patients were subjected to history taking, clinical examination, and laboratory investigations as ESR and serum adiponectin level. Also severity of primary knee O.A was determined by using K-L grading radiography, WOMAC score and TUG test.
Statistical analysis revealed:
1. There was a non-significant difference between the cases and the controls regarding age, sex and the mean value of BMI.
2. There was a highly significant difference between patients and controls regarding the adiponectin level.
3. There was a significant positive correlation between age of patients and adiponectin level.
4. There was a highly significant positive correlation between the disease duration and the adiponectin level.
5. There was a highly significant positive correlation between the disease duration and the Kellgren Lawrence grading.
6. There was a non-significant correlation between BMI, ESR of patients and adiponectin level.
7. There was a significant difference between adiponectin levels among patients who showed bilaterality, jelling phenomenon and ligament laxity and highly significant difference in patients showed effusion compared with patients without these manifestations.
8. There was a highly significant positive correlation between Kellgren Lawrence grading of patient’s knees and adiponectin level.
9. There was a highly significant positive correlation between TUG test results and adiponectin level (The more the time of the test, the higher the adiponectin level).
10. There was a highly significant positive correlation between WOMAC score results and adiponectin level (The higher the score, the higher the adiponectin level).
11. ROC curve (receiver operating characteristic) showed that Adiponectin level can be used for diagnosis of cases at a level of 4.0 µg/ml with 70% sensitivity and 53% specificity.
We can conclude from these results that:
Serum adiponectin levels were higher among patients with primary knee OA and were correlated with more severe OA. Measurements of serum adiponectin could possibly serve as a biochemical parameter for determining disease severity and may be predictive of prognosis with respect to the progression of osteoarthritic disease process.