الفهرس 
Multiple sclerosisOnly 14 pages are availabe for public view
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Abstract
Multiple sclerosis (MS) is a chronic inflammatory demylinating autoimmune disease of CNS , characterized clinically by progressive loss of neurological function caused by the destruction of the axonal myelin sheath of the brain and the spinal cord, leading to disabilities such as paralysis, optic neuritis, muscle spasms, and neuropathic pain, this condition has gained importance due to increasing incidence rate worldwide that affects more than two million people worldwide between the ages of 20–40 years, with affected women to men 3:1. MS is considered the primary cause of non-traumatic disability in young adults.
The exact cause of MS remains unknown; however, it is likely to result from complex interactions of susceptibility genes, environment, and immune system, many medical therapies have been proposed for management of MS such as glucocorticoids, and immunosuppressive; but available drugs result in marked deleterious effects, so there must be more investigations to find novel therapy and new targets in the management of MS.
Experimental autoimmune encephalomyelitis (EAE) most commonly used as an experimental animal model of MS with a similar features of MS: inflammation, demyelination, axonal loss and gliosis. MOG induced EAE is very encephalitogenic and produce strong T and B cell responses and characterized by relapsing-remitting neurological disease with plaque-like demyelination with clinicopathological picture closely resembles MS in human.