الفهرس 
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Abstract
This study aimed to evaluate the effect of topical application of SrRan on induced bone defect healing in guinea pigs.Twelve adult guinea pigs with an average weight of 350-500 gm. were used in this study. All animals were kept under the same nutritional and environmental conditions. Each animal was subjected to implantation of strontium ranelate (SrRan) granules (Servier Industries, France) in surgically induced bony cavity in the right side of the submental area of the mandible. Moreover, a second bony cavity of the same size was induced on the left side without application of (SrRan) granules to serve as control. After operation the animals were transferred to their cages for daily observation till complete recovery. At 2, 4, and 6 weeks, the animals of all groups were sacrificed and divided equally among groups A, B, and C respectively. After sacrificing the animals, their mandibles were separated for preparation of paraffin blocks and histological evaluation.The histological sections of control group revealed that healing of the bony cavities proceeded in a normal sequence of bone healing starting from 2 weeks and completed at 6 weeks. While the histological finding in study group showed delay in bone defect healing started from cavity wound with an empty space and a condensation of granulation tissue at the cavity opening after 2 weeks. At 4 weeks the experimental sections informed that bridge of bone at wound opening, granulation tissue seen at cavity center. At 6 weeks the experimental sections showed appearance of heavy condensation of granulation tissue with thin bone trabeculae could be seen.Regression analysis using two-way analysis of variance (ANOVA) was performed. The results showed that bone healing in non-applied SrRan cavities was significantly difference with the topically applied SrRan cavities which may be indicator that topical application of SrRan may delay the bone healing.