الفهرس 
Migraine
The Vascular TheoryOnly 14 pages are availabe for public view
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Abstract
Migraine is a recurrent neurovascular disorder which
lowers the quality of life. Severe head pain, in addition to
the symptoms of nausea and vomiting, is the most
bothersome complaint of these patients. Usually, light and
sound can have an effect on the severity and frequency of
these symptoms. Middle-aged women are more susceptible
to migraine occurrence than men. It is divided into
migraine with aura or migraine without aura (Sadeghi et
al., 2016).
Molecular genetic studies of migraine have
investigated many polymorphisms possibly associated with
migraine. The most common examined gene is MTHFR
gene polymorphism (Kowalska et al., 2016).
MTHFR enzyme plays a key role in homocysteine
metabolism and DNA methylation which is encoded by
MTHFR gene. MTHFR gene polymorphism C677T
reduces the enzymatic activity resulting in increased
homocysteine concentrations, and reduced methylation
capacity (Tsang et al., 2015).
This study was conducted on 45 subjects who were
divided into two groups.GroupI (patients group) which
included thirty (30) adult patients with migraine recruited
from headache clinic in Ain Shams University hospitals,
they were diagnosed with migraine according to ICHD
diagnostic criteria 3rd edition beta version (2013) and group II (control group) which included 15 age and sex
matched apparently healthy subject.
The present study aimed to assess the association
between MTHFR gene polymorphism and different types
of migraine.
The results of the present study revealed that there was
a significant difference between MTHFR gene
polymorphism (C677T) and migraine (P<0.05).
When comparative statistics was done between
genotypes of MTHFR gene polymorphism and different
clinical data of migraine it showed highly significant
difference between aura and MTHFR gene polymorphism.
Homozygous TT genotype was higher in patients suffer
from aura.
Regarding the associated symptoms of migraine, the
study showed significant difference between MTHFR gene
polymorphism and photophobia and phonophobia.
Heterozygous genotypes (CT) was higher in patients suffer
from photophobia and phonophobia
No significant difference between other clinical data
of migraine and MTHFR gene polymorphism.
In conclusion, this study had demonstrated that there
was a significant difference between MTHFR gene
polymorphism (C677T) and migraine .Patients with
heterozygous type (CT) more susceptible to aura while
patients with homozygous type (TT) more susceptible to
attack of migraine associated with photophobia or
phonophobia or both.