الفهرس 
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Abstract
Despite improved neonatal care over the past decades, infections remain common and sometimes life-threatening in neonates admitted to the neonatal intensive care unit (NICU).
Unfortunately there is no single diagnostic test, which can reliably diagnose sepsis in the newborn, therefore many diagnostic tests are utilized to diagnose or confirm sepsis.
This study was conducted in order to evaluate serum level of vitamin D in early onset neonatal sepsis.
This study was conducted on 50 neonates presenting with symptoms and signs suggesting neonatal sepsis, admitted to NICU of Minia University Hospital of Obstetrics and Pediatrics. In addition, 30 healthy neonates as controls.
Weak suckling, weak Moro, lethargy and respiratory distress were the commonest presentation of sepsis in our study followed by GIT manifestations, while sclerma and bleeding tendency were the least presentations of sepsis.
Our study revealed higher significant difference regarding TLC between patients and controls.
Also there was highly significant increase regarding I/T ratio was observed in the patients group when compared with that of the controls.
It revealed significant difference regarding HB level and platelet count between patients and controls.
In our study CRP level was found to be very highly significant statistically between septic group and controls.
In this study, the sensitivity and the specificity of CRP were 73.9% and 88.9 respectively at a cut off point of 15.5 mg/l.
In our study, serum level of 25(OH) D was found to be very significant statistically between septic group and controls. There was significant decrease in serum level of 25(OH) D in septic neonates.
In the current study, as regarding 25(OH) D, the sensitivity was 100% and the specificity was 100% at a cut off point of 19.1 ng/ml.
In conclusion, serum 25(OH) D levels of neonates with EONS were significantly lower than that of the healthy controls.
Also 25(OH)D level may be used as an adjunctive marker in diagnosis of neonatal sepsis.