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Abstract Skin is a soft tissue that forms about 8% of the total body mass and covers the entire surface area. It is a self-repairing, self-renewing organ in the body that forms an important barrier from the outer environment to the inner environment, temperature regulation, fluid maintenance and sensory control. Burn injuries are one of the most complex and painful physical injuries to treat and manage. Burn injury is associated with a significant incidence of death and disability, prolonged hospitalization and rehabilitation and high health care costs. Despite the evolution of antiseptics, medications and advanced operative procedures, healing of burn injury is still difficult to achieve. The focus on plant research has increased all over the world. Herbal products seem to possess moderate efficacy with no or less toxicity and are less expensive as compared with synthetic drugs. One of the golden treatments in topical burn is aloe vera plant, which has been known and used for centuries for its health and skin care. This herb has been reported to reduce inflammation and facilitate burn healing. In recent years, stem cells therapies have emerged as therapeutic alternatives for regeneration and repair of damaged organs and tissues in various diseases including burn. Stem cells have been shown to improve healing by differentiating into new tissue. This work was performed to investigate the therapeutic effect of intradermal injected bone marrow derived mesenchymal stem cells versus topical aloe vera on female rats skin subjected to deep second degree burn after 14 and 21 days of treatment, using the histological techniques. |