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العنوان
Fructosamine and Hemoglobin A1c for Assessing Glycemic Control in Type I Diabetic Children with and without Iron Deficiency Anemia /
المؤلف
Mahmoud, Ahmed Roshdy.
هيئة الاعداد
باحث / أحمد رشدي محمود
مشرف / جمال طه سليمان
مشرف / محمد هاشم محمد محجوب
مشرف / نجوي إسماعيل عقيلي
الموضوع
Diabetes in children. Diabetes in adolescence. Diabetes Mellitus - Adolescent. Diabetes Mellitus - Child.
تاريخ النشر
2017.
عدد الصفحات
89 p.
89 p. :
اللغة
الإنجليزية
الدرجة
ماجستير
التخصص
طب الأطفال ، الفترة المحيطة بالولادة وصحة الطفل
تاريخ الإجازة
1/1/2017
مكان الإجازة
جامعة المنيا - كلية الطب - طب الاطفال
الفهرس
Only 14 pages are availabe for public view

from 101

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Abstract

The incidence of type I diabetes is rising worldwide, particularly in young children. Type I diabetes is considered a multifactorial disease with genetic predisposition and environmental factors participating. Strict glycemic control is essential for preventing the complications of diabetes.
HbA1c levels provide an estimate of plasma glucose levels during the preceeding 1-3 months. Serum fructosamine generally reflects the state of glycemic control for the preceding 2-3 weeks.
Anemia is relatively common in patients with diabetes mellitus, and it contributes to many clinical aspects of diabetes mellitus or its progression diseases. The possibility of the coexistence of type 1 DM and iron deficiency is higher than any other type of anemia.
Concerning the laboratory parameters; Hb, MCV, MCH and serum ferritin levels were significantly lower in our diabetic children with IDA than in our diabetic children without anemia.
HbA1c levels in our study were significantly higher in diabetic children with iron deficiency anemia (9.82±1.74 %) than diabetic children without anemia (8.5±2.07 %) (p< 0.001). There were insignificant differences between our diabetic children with and without IDA regarding both mean blood glucose levels at the last three weeks (p=0.904) and fructosamine (p=0.096).
In our diabetic children without anemia, there were significant higher levels of HbA1c and fructosamine in uncontrolled patients (9.31±1.74% and 834.64±267.51 µmol/L respectively) than controlled patients (7.02±1.8% and 548.43±292.81µmol/L respectively) (p< 0.001 in both). While in diabetic children with IDA, there were insignificant differences in levels of both HbA1c and fructosamine between uncontrolled and controlled patients (p=0.174 and p=0.548 respectively).
Our study showed significant positive correlations between mean blood glucose and both HbA1c and fructosamine in our diabetic children without anemia (p<0.001 and p<0.001). While in our diabetic children with IDA, there were insignificant correlations between mean blood glucose and both HbA1c and fructosamine (p=0.058 and p=0.248 respectively). There were significant positive correlation between HbA1c and fructosamine in our diabetic children with and without IDA (p<0.001 and p<0.001).