الفهرس 
IntroductionOnly 14 pages are availabe for public view
 |  | from | 126 |  |  |
| | | from | 126 | | |
Abstract
Idiopathic thrombocytopenic purpura (ITP) is a disorder that can
lead to easy or excessive bruising and bleeding. The bleeding results from
unusually low levels of platelets , the cells that help blood clot
Immune thrombocytopenia (ITP) is autoimmune destruction of
platelets in addition to suppression of platelet production by the bone
marrow (BM) megakaryocytes. The diagnosis of ITP depends on
demonstration of a platelet count < 100 × 109/L and may be found in
isolation (primary) or alongside other autoimmune and medical
conditions (secondary) .
Interleukin-23(IL-23) is proinflammatory cytokine among the four
heterodimeric cytokines of IL-12 family.
Interleukin 23 (IL-23) is a heterodimeric pro-inflammatory cytokine
comprising IL-12 subunit p40 and IL-23 subunit p19. IL-23 is secreted by
activated dendritic cells and macrophagesand is a crucial member in the
innate immune system.
The aims of this study was to evaluate the role of IL-23 in diagnosis
of Idiopathic thrombocytopenic purpura.
A total of 5 papers were obtained using the mentioned keywords in
the research of all internet-based databases.
The total number of cases in all of the studies was 239 cases.
The mean age was recorded in 5 papers, and the mean age of each of
them was 32.8 years.
107
There are different method of detection of IL23 in different study
such as PCR ,ELISA and flow cytometry
These findings suggest that levels of IL-23 are significantly
higher in ITP patients.
Conclusion
In conclusion, the results of our research suggest that the levels
IL-23 are significantly higher in ITP patients.