الفهرس 
Aim of WorkOnly 14 pages are availabe for public view
 |  | from | 105 |  |  |
| | | from | 105 | | |
Abstract
Early pregnancy loss is a common pregnancy complication in clinical practice, the time delay to distinguish viable from nonviable pregnancy is often distressing to patients and doctors.
The major role of ultrasound in the first trimester of pregnancy is to establish the presence of a normal live intrauterine pregnancy and to distinguish this from either pregnancy failure or ectopic pregnancy. No single ultrasound measurement of the different anatomical features in the first trimester has been shown to have a high predictive value for determining early pregnancy outcome.
A highly sensitive and specific biomarker that accurately discriminates between viable and non-viable pregnancy would be useful for early intervention.
The CA-125 tumor marker is a cell-surface antigen, derived from the surface coelomic epithelium, including the mucosa of the entire female genital tract and the germinal epithelium of the ovaries. The fetalchorion, amniotic fluid and maternal decidua have also been shown to contain significant amounts of CA-125 protein. The most likely source of the CA-125 during pregnancy is the decidua and not fetal tissues or amnion. Vaginal bleeding in early pregnancy is associated with decidualdestruction. Mechanical disruption of the decidua at the time of imminent abortion leads to the release of CA-125 into maternal blood.
The objective of the present study was to investigate the relationship between maternal serum level of CA125 in prognosis of pregnancies complicated by first-trimester bleeding .
This prospective study was conducted on 100 women in their first trimester of pregnancy divided into 50cases group and 50 control group attending the outpatient clinic or the casualty department of Obstetrics & Gynaecology, EL Fayoum general Hospital.
All the Patients aged between 25 to 35 years were in their 1st trimester of a viable singleton spontaneous pregnancy i.e. no history of induction of ovulation, presenting with vaginal bleeding or spotting. Gestational age ranged (7-13) weeks calculated from the 1st day of the last normal menstrual period, preceded by 3 regular menstrual cycles, and correlating with ultrasound measurements, together with positive urinary pregnancy test.
The study group consisted of one hundred (100) women divided into 50 cases group and 50 control group. The case group with clinical diagnosis of threatened abortion was further subdivided during follow up into: group of patients who aborted (17) patients and another group who continued their pregnancy and proceeded into the second trimester (33) patients.
The incidence of abortion in the current study was (17%). women of the two study groups were not significantly different as regards gravidity, maternal age, number of abortion.
There were statistically significant differences between threatened abortion, aborted and continued group as regards the maternal serum level of CA-125. As the aborted group showed a higher level of CA-125 compared to low level of CA-125 in the continued group.
Finally, estimation of serum level of CA125 in patients with threatened abortion are attempts to develop a rapid, cheap and sensitive methods for anticipating the pregnancy outcome.