الفهرس 
Acknowledgements
Oxygen concentratorsOnly 14 pages are availabe for public view
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Abstract
LTOT has dramatically altered the outlook for many patients with significantly hypoxemic COPD and has the potential to improve life quality and duration for others not currently included in prescription guidelines. Future directions in LTOT research are needed to better identify which patients are most likely to benefit from this therapy, how adherence with LTOT can be enhanced, which clinical outcome, how it can be most efficiently and cost effectively delivered .
A total of 50 COPD patients (32male and 16 female ) randomly selected from patients admitted Chest department at Assuit University Hospital.in the period from October 2015 to October 2016 Who were prescribed to LTOT according to BTS guidelines .
All patients were subjected to the following:
1- History taking and clinical examination.
2- Pulmonary function test.
3- Six minutes walking test (SMWT) .
4- St George’s Respiratory Questionnaire(SGRQ)
5- -Arterial blood gases (ABG).
The following results were observed :
*patients experienced improvement in quality of life with significant statistical changes in SGRQ among all components (activity , impact , symptom and total score ) which run with previous RCTs .
* Survival outcome after one year follow up among 50 COPD patients around 87 % which run with the two previous important trials (NOTT 1980) and (MRC 1981) and reflect the clinical importance of oxygen therapy.
* patients show significant reduction in number of hospitalization after usage of LTOT (p <0.05) in comparison to the previous number of hospitalization prior to LTOT .
* follow up of exercise tolerance of the studied patients by measuring oxygen saturation during SMWT show no significant difference after 3 months follow up while after 6 months follow up remarkable improvement which is statistically significant of O2 saturation was observed .
* follow up of patients regard PFTs and also regard BMI show no significant change after 3 and 6 months follow up .