الفهرس 
PreeclampsiaOnly 14 pages are availabe for public view
 |  | from | 157 |  |  |
| | | from | 157 | | |
Abstract
In preeclampsia there is an immunologically mediated deficiency in the trophoblastic invasion of the placental bed by spiral arterioles resulting in poorly perfused fetoplacental unit, which in turn secrets mediators into the maternal blood causing the multisystem pathological changes which are characteristic for preeclampsia. VEGF possesses many of the characteristics required for a candidate circulating factor to be one of these preeclamptic mediators (54). Vascular endothelial growth factor (VEGF) is a glycosylated glycoprotein which has a vasodilator and vascular permeability inhancing effects, in addition to angiogenic and a potent endothelial cell mitogenic property (62). The aim of the work was to find if serum level of vascular endothelial growth factor shows changes with the onset of preeclampsia that could be used as predictor for preeclampsia. This study included 60 primigravidae women divided into three groups, group (I) included 20 normal women, group (II) included 20 women with mild preeclampsia and group (III) included 20 women with severe preeclampsia. The results of this study revealed that VEGF concentrations measured in severe preeclampsia group were significantly higher than mild preeclampsia group and control group. Thus VEGF concentrations could be used as a predictor for diagnosis and follow up of severity of preeclampsia. Vascular endothelial growth factor (VEGF) had significant value for discrimination between patients with PE (mild & severe) and controls with cutoff value >632.4 ng/l which had a sensitivity of (82.5%) and specificity of (85%), also serum VEGF concentration for discrimination between patients with severe PE and those with mild or no PE was >1335.5 ng/l, with specificity of (92.5%) and sensitivity of (90%). Vascular endothelial growth factor (VEGF) had significant value for prediction of adverse fetal outcomes with cutoff value >741.5 ng/l which had a sensitivity of (95.65%) and specificity of (72.97%). According to the previous data obtained, serum VEGF level can be used as a predictor for preeclampsia.