الفهرس 
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Abstract
The present work was carried out to study the anti-oxidant and anti-DNA damaging as well as the anticancer activities of spirulina in comparison with cisplatin. To assess the protection of Sp on CDDP-induced hemato, hepato- and nephro-toxicity, female Swiss mice were treated with Sp (0.5 g/kg BW, p.o.) for 30 days and/or CDDP (40 µg/mouse, i.p.) for 15 days at gps ( II, III and IV). For evaluating the antitumor activity of Sp and/or CDDP against EAC, EAC-bearing female Swiss mice (2.5×106 EAC/0.2 ascetic fluid /mouse) were treated with Sp and/or CDDP at gps (V,VI, VII and VIII) by the same dose and duration as mentioned before . All experimental groups were compared to negative control group of animals which were kept without medication (gp. I). Daily observation for clinical signs and survival analysis were recorded. Ascitic fluid, blood, serum, liver, kidney and peritoneum were collected for selective clinico-pathological, histopathological and immunohistochemical examinations.
Regarding the toxic study, by clinical signs observation of mice at gps (I-IV), no mortalities were recorded. Comparing with the control gp. (I), mice of gp. (II) were apparently normal meanwhile, gp. (III) lost their fur, body weight and activity but these signs were improved at gp. (IV(. Furthermore, the clinicopathological analysis revealed that BM smears of gp. (III) showed marked depletion which resulted in a significant decrease in the counts of all peripheral blood cell elements caused signs of aplastic anemia. Besides, a significant increase in their serum activities of liver enzymes, kidney byproducts, hepatic and renal MDA content in addition to marked hypoproteinemia, hypoalbuminemia and lowered hepatic and renal SOD and GSH contents were also observed. All the fore-mentioned alterations were improved in gp.(IV).