الفهرس 
PreeclampsiaOnly 14 pages are availabe for public view
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Abstract
Backgroud: Magnesium sulfate (MgSO4) is used in women with severe preeclamptic toxemia for neuroprotection from seizures and can help to prevent serious complications
Objective: To assess the effect of MgSO4 before and after its administration on Doppler ultrasound parameters of fetal umbilical artery (UA) and middle cerebral arteries (MCA) in pregnant women with severe pre-eclampcia.
Patients and Methods: A total of 52 patients with severe preeclampsia admitted to Ain Shams University Maternity Hospital were evaluated. Before and after administration of magnesium sulfate, Doppler ultrasound scan was carried out to measure umbilical artery and fetal middle cerebral artery blood flow. Paired t-test was used for statistical analysis.
Results: After injection of magnesium sulfate, the mean resistivity index (RI)-umbilical, and pulsatility index (PI)-cerebral showed a statistically significant reduction (P < 0.001). The cerebroumbilical C/U ratio increased after the intervention (P < 0.001). The PI-umbilical (P = 0.1) and pre- and post-RI-cerebral (P = 0.96) did not have statistically significant changes.
Conclusions: Infusion of magnesium sulfate significantly decreases the flow in the fetus RI-umbilical and PI-MCA, and it increases C/U ratio indices in color Doppler ultrasound.