الفهرس 
MisoprostolOnly 14 pages are availabe for public view
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Abstract
Introduction: Hysterectomy is the surgical removal of the uterus. It is the most frequently performed major gynaecological surgical procedure, with millions of procedures performed annually throughout the world Hysterectomy can be performed for benign and malignant indications. Approximately 90% of hysterectomies are performed for benign conditions.
Aim of the Work: The aim of the present study is to investigate whether preoperative administration of sublingual misoprostol is beneficial in reducing intraoperative blood loss among women undergoing total abdominal hysterectomy.
Patients and Methods: Study Design: Single-blind, randomized, placebo-controlled trial. Study setting: This study was performed at Ain Shams University Maternity Hospital
Population: One hundred and twenty three patients were recruited from the obstetrics and gynecology department and One hundred and eighteen patients were enrolled in the current study.
Results: group A: Patients undergoing total abdominal hysterectomy and received 400 μg of Misoprostol 30 minutes before operation (59 patients).group B: Patients undergoing total abdominal hysterectomy and received Placebo 30 minutes before operation.(59 patients).
Conclusion: This study concludes a single preoperative dose of 400 μg of misoprostol administered 30 minutes before abdominal hysterectomy resulted in a significant reduction of blood loss and the subsequent need for blood transfusion and risk of morbidity related to anemia.