الفهرس 
Review of literature.Only 14 pages are availabe for public view
 |  | from | 269 |  |  |
| | | from | 269 | | |
Abstract
Abstract
Euphorbia dendroides belongs to family Euphorbiaceae in the past was used in full strength to burn warts and verrucas and very diluted as a strong purgative or in even lighter concentration as an emetic. Powder from the roots was used to cure rheumatic pains.
The aim of this study is to evaluate the Hepatoprotective activity against hepatotoxicity induced by CCl4, cytotoxic, antimicrobial activities of Euphorbia dendroides extracts(ethanolic, chloroform, butanol). This effects are attributed to the isolated compounds from the extract.
This aim was achieved through estimation of some biochemical parameters(liver function tests, oxidative stress biomarkers, proinflammatory markers) and histopathological examination of liver tissues from all groups. In addition to determination of IC50 of extracts against different human cancer cell lines (HEP-G2, MCF-7, HCT-116, HELA) and MIC of all extracts against diferrent strains of bacteria and fungi.
Conclusion: Our results indicated that Euphorbia dendroides chloroform extract has a hepatoprotective activity against acute hepatotoxicity induced by CCl4 in rats . On the other hand, all Euphorbia dendroides extracts have cytotoxic and antimicrobial activities. Isolation and identification of active ingredients from chloroform extract gave 3 main compounds which were identified by means of 1H-NMR as Ursodeoxycholic acid, Genistein and 17-(2-hydroxy-1,5-dimethyl-hex-4-enyl)-4,4,10,13,14-pentamethyl-2,3,4,5,6,7,10,1
Key words: Euphorbia dendroides, hepatoprotective, cytotoxic, antimicrobial.