الفهرس 
(Anemia in chronic kidney disease (CKD)Only 14 pages are availabe for public view
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Abstract
Introduction Cytomegalovirus (CMV) is a double-stranded DNA virus of the family Herpesviridae. Humans are the only natural hosts of CMV, and infections are common; the seroprev¬alence ranges from 45% to 100%. CMV is more common in Asia, South America, and Africa than in Western Eu¬rope or the United States.
CMV lesions may be caused by primary infection or reactivation of latent virus, or may develop when a se¬ropositive patient is reinfected via transplantation or blood transfusion.
Many subjects are exposed to CMV via inapparent infections during early childhood. After initial infection,
Aim of the work: This retrospective study aimed at detecting the seroprevalence of CMV antibodies, and its association with transfusion of non-leucocyte reduced blood among patients undergoing chronic hemodialysis
Methods
We used this retrospective study to analyse the data of ninety nine chronic kidney disease patients on hemodialysis thrice a week at the Ain Shams University Hospital, Cairo, Egypt. And collected data such as age and six, hemodialysis vintage, iron and erythropoietin-stimulating agent (ESA)and iron therapies for anemia, and transfusion history and frequency for analysis. Blood analyses for the presence of CMV-specific immunoglobulin (IgG) and (IgM) were performed at the Microbiology laboratory at AIN Shams University Hospital. Statistical analyses were performed using the SPSS version 20.0 for Windows. Continuous variables were presented as mean, standard deviation (SD), median, and ranges. Categorical data were presented as counts and percentages and analysed by the Pearson’s Chi-square test. A two-sided P value <0.05 was considered statistically significant.
Results
There was a significant association with seroprevalence of CMV and frequent blood transfusions. Associations between age, sex, and presence of CMV-specific IgG and IgM, and CMV seroprevalence were not significant.
Conclusion
Frequency of blood transfusion can be considered as a major risk factor for the seroprevalence of CMV in immunocompromised patients, on and further studies are required to follow up those patients undergoing kidney transplant to detect impact of repeated blood transfusion and increased CMV seroprevelance in such patients on graft and patient outcome .