الفهرس 
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Abstract
Osteoarthritis (OA) is the most common form of arthritis and is characterized by gradual cartilage loss, eventually resulting in functional failure of synovial joints(Brand et al., 2011).
25-(OH)D appears to be implicated in structural changes of knee OA rather than symptoms and further well-designed RCTs are required to determine whether vitamin D supplementation can slow disease progression (cao et al., 2013).
The present study was designed to find possible association between knee OA andserum 25-(OH)D and to evaluate its significance as a marker of disease activity and joint destruction in patients with osteoarthritis.
We conducted our study on fifty OA patients and twenty healthy subjects serving as control group. All patients and control groups were subjected to history taking, ,self reported KATZ index, clinical examination, laboratory investigations as CBC, ESR, SGOT, SGPT, fasting blood sugar, serum urea , creatinine, complete urine analysis, Serum level of 25-Hydroxycholecalciferol were measured using direct ELISA technique and radiological score was done according to (Kellgren and Lawernce, 1957).
Serum level of 25-hydroxycholicalciferol is sufficient in 24 patients (48%), insufficient 16 patients (32%) and deficient in 10 patients (20%).
By comparing the clinical, radiological and laboratory findings in the three groups of patients, there were highly significant differences:
As regards disease duration, we found that insufficient and deficient groups had longer disease duration than sufficient group with highly statistical difference
As regards pain assessment by Katz Index of Independence in Activities of Daily Living score for pain and functional assessment our comparison studies showed higher lower score in both insufficient and deficient groups compared to KATZ Index in sufficient group with highly statistical difference.
As regards x-ray grading, comparison studies showed that patients with higher grades of X-ray (III, IV) had lower serum level of 25-hydroxycholicalciferol and lower grades of X-ray (I, II) had higher serum level of 25-hydroxy cholicalciferol with highly statistical difference.
The results of the present study provide that serum level of 25 Hydroxycholecalciferol has highly significant negative correlations with disease duration and knee plain x-ray and highly significant positive correlation with KATZ index.