الفهرس 
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Abstract
The present study was conducted on 50 subjects divided into 2 groups: group I included 30 vitiligo patients and group II (controls) included 20 age and sex matched healthy volunteers. For all participants, thorough history taking, good general and dermatological examination were done. In addition, VIDA scoring and ACE insertion/dilation (I/D) genotypes by polymerase chain reaction technique (PCR) were assessed.
Results of the current study showed significant high frequency of ACE DD genotype (P < 0.001) among vitiligo patients (63.3%) than controls (15%). Moreover, vitiligo patients had significantly (P<0.001) increase in D allele than controls, compared to wild allele (I allele).
No significant differences were observed among the studied ACE genotype groups regarding their disease characteristics (duration, VIDA scoring, extent of lesion%, clinical types, classification and course) in vitiligo patients (P>0.05 for all). Additionally, no significant correlations could be detected between the studied demographic characteristics (age sex) of patients with vitiligo and ACE genotypes (r= 0.346, P= 0.63 r=0.236, P=0.72, respectively) Conclusions
In the light of the present study findings, it can be concluded that:
•ACE gene polymorphism may have an active role in
aetiopathogenesis of vitiligo and participate in its development.
•ACE gene polymorphism may be a new target of treatment for
patients with vitiligo.