الفهرس 
? Type 2 Diabetes MellitusOnly 14 pages are availabe for public view
 |  | from | 172 |  |  |
| | | from | 172 | | |
Abstract
Background: T2DM is a metabolic disorder that is characterized by high blood glucose in the context of insulin resistance and relative insulin deficiency with disturbances of carbohydrate, fat, and protein metabolism.T2DM is a risk factor for Alzheimer’s disease and mild cognitive impairment. The aetiology of cognitive impairment in people with T2DM is uncertain, but it is most likely multi factorial. chronic hyperglycaemia, cerebral micro vascular disease, severe hypoglycaemia, and increased prevalence of macro vascular disease have all been implicated but are unlikely to explain the entire effect.
Aim of the work: The aim of the study was to determine the serum levels of soluble vascular adhesion molecule (sVCAM-1) and hs-CRP in elderly type 2 diabetics with mild cognitive impairment (MCI).
Patient and Methods: Our study was conducted on 90 elderly subjects (aged 60 years old or more) selected from diabetes inpatient and outpatient clinic at internal medicine and geriatrics departments, Ain Shams University Hospitals from June 2016 to February 2017. A written consent was obtained from the participants at the beginning of the study.
Results: Our study was conducted on 90 subjects ( aged 60 or more), 60 persons (66.6%) were males and 30 persons (33.3%) were females (table 8), with mean age (66.1556 ± 4.37796 years) selected from diabetes inpatient and outpatient clinic at internal medicine and geriatrics departments, Ain Shams University Hospitals.
Conclusion: In our study we demonstrated that elderly diabetic patients with mild cognitive impairment, have higher levels of soluble adhesion molecules and markers of low-grade systemic inflammation than other groups.