الفهرس 
? ThalassemiaOnly 14 pages are availabe for public view
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Abstract
Background
Thalassemia refers to a spectrum of diseases characterized by reduced or absent production of one or more globin chains, causing defective hemoglobin formation. They are a group of genetic disorders that affects the synthesis of alpha or beta chains or both.
Aim of the Work:
The aim of this study is to evaluate the myocardial performance using conventional echo and its relation to brain naturetic peptides (PNP) level as a sensitive biomarker for early detection of cardiac affection.
Patients & Methods
This is a cross sectional study that was conducted in the clinical hematology department in Ain Shams University hospital.
The study included 45 patients and 30 controls.
Inclusion Criteria:
• Transfusion dependent thalassemia patient.
• Aged from 16 to 45 years.
Exclusion criteria
• Any signs of decompensated heart failure.
• Congenital heart disease.
• Ischemic heart disease
Results:
Our results have shown a strong statistical positive correlation between the BNP level in thalassemia patients compared to the control group and thalassemia major compared to intermediate and compared to the control.
There is a statistically significant correlation between the BNP level and the frequency of iron transfusion and the serum ferritin level.
There is a statistically significant correlation between the BNP level and the elevated right ventricular pressure.
Conclusion
There is a controversy between different studies to correlate it with iron overload. It is also influenced by several factors so it wouldn’t be accurately to iron cardiomyopathy especially in the thalassemia patients