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العنوان
Stem Cells Mediated Therapy Versus Neurotrophins after Experimentally Induced Spinal cord Injury in Adult Albino Rat :
المؤلف
Hamada, Amal Mohammed Abdel Sattar.
هيئة الاعداد
مشرف / امل محمد عبدالستار حماده
مشرف / مني محمد موسي زعير
مشرف / مني محمد علي عطية
مشرف / دعاء عادل محمد هيبه
الموضوع
Anatomy. Human Anatomy &<br>Embryology Department Human Anatomy Embryology.
تاريخ النشر
2017.
عدد الصفحات
166 ص. :
اللغة
الإنجليزية
الدرجة
الدكتوراه
التخصص
تشريح
تاريخ الإجازة
20/9/2017
مكان الإجازة
جامعة طنطا - كلية الطب - Human Anatomy& Embryology
الفهرس
Only 14 pages are availabe for public view

from 273

from 273

Abstract

Spinal cord injury (SCI) is a severe problem caused by car accidents or direct trauma. It results in marked motor and sensory disabilities that affected the ordinary life. So, many researchers were interested in this case and experimentally induced SCI was done in many studies. Mesenchymal stem cells are a new area of research and it is considered as a promising effective therapy nowadays. It was used as a trial to treat cases of SCI. Bone marrow derived mesenchymal stem cell (BM-MSCs) therapy resulted in improvement of the post injury sequel. Most of pathological changes and the motor disability were reversed. Cerebrolysin (CBL) is a mixture neurotrophic factors which enhance synaptic plasticity and neuronal survival. CBL could be used in many neurological disorders including the spinal cord injury. Aim of the work: This experimental study was designed to throw the light on the possible role of stem cell-based therapy versus neurotrophic factors ”cerebrolysin” for repairing the injured spinal cord. Material & methods: In this work, 10 rats were used for BM-MSCs extraction and 80 rats were equally divided into 4 groups as follows: - group I (control group): divided equally into two subgroups; subgroup Ia. (negative control left without any manipulation) andsubgroup Ib. (positive control or Sham operated group) which were subjected to laminectomy only without spinal cord injury.