الفهرس 
IntroductionOnly 14 pages are availabe for public view
 |  | from | 131 |  |  |
| | | from | 131 | | |
Abstract
BD is a multisystem disease characterized by recurrent oral and genital ulcers, relapsing uveitis, articular, gastrointestinal, neurologic, and vascular manifestations. BD is multifactorial, Genetic, environmental and immunological factors are implicated in its pathogenesis.
Paraoxonase 1is believed to play an important role in protection of LDL and HDL particles from oxidation, in antioxidant effect against lipid peroxidation on cellular membranes, and in anti-inflammatory process. Lipid peroxidation and free oxygen radicals have been thought to play a role in pathogenesis of BD.
The current study aimed to current study aimed to current study aimed to current study aimed to current study aimed to current study aimed to current study aimed to current study aimed to current study aimed to current study aimed to current study aimed to current study aimed to current study aimed to current study aimed to current study aimed to current study aimed to current study aimed to current study aimed to current study aimed to current study aimed to current study aimed to current study aimed to current study aimed to study paroxonase 1- L55Mgene polymorphisms in BD and its relation to clinical manifestations.
We examined e examined e examined e examined e examined e examined e examined e examined e examined e examined e examined 40 BD (group BD (group BD (group BD (group BD (group BD (group BD (group BD (group BD (group BD (group II ). ). ). The diagnosis of Behcet’s Disease was made according to International Study group Criteria of Behcet’s Disease (ISG, 1990).We had We had We had We had We had We had We had 40 healthy adult persons ashealthy adult persons ashealthy adult persons ashealthy adult persons ashealthy adult persons ashealthy adult persons ashealthy adult persons ashealthy adult persons ashealthy adult persons ashealthy adult persons ashealthy adult persons ashealthy adult persons ashealthy adult persons ashealthy adult persons ashealthy adult persons ashealthy adult persons ashealthy adult persons ashealthy adult persons ashealthy adult persons ashealthy adult persons ashealthy adult persons ashealthy adult persons ashealthy adult persons ashealthy adult persons as a control (group I). a control (group I). a control (group I). a control (group I). a control (group I). a control (group I). a control (group I). a control (group I). a control (group I). a control (group I). a control (group I). a control (group I). a control (group I). a control (group I). a control (group I). a control (group I). a control (group I). a control (group I). a control (group I). a control (group I). All patients were subjected to thorough history taking, physical examination, investigations including complete blood count, erythrocyte sedimentation rate, C-reactive protein, Serum Lipid profile: Total cholesterol, Triglycerides, HDL-c and LDL-c, Fundus and slit lamp examination for patients with eye manifestations, CT brain for patients with CNS symptoms, Duplex study of blood vessel for patients with symptoms of blood vessel affection, Paroxonase1-L55M gene study using PCR-RFLP.
Our study revealed that BD shows male predominance with male: female ratio (2.1:1). The age at the onset of the disease ranges between 18 – 30Y old (mean 24 y)
The initial presenting symptoms were oral ulcers (95 %), genital ulcer (2.5 %) and ocular symptoms (2.5 %).
Oral and genital ulcers were present in all BD patients. Eye lesion was present in (67.5 %) patients in the form of anterior and posterior uveitis (55 %), (17.5 %) respectively. Skin lesion was present in (40 %) patients in the form of EN and folliculitis (10 %), (30 %) respectively. Pethargy test was positive in (30%) patients. Vascular involvement was present in (42.5 %) in the form of arterial and venous thrombosis (17.5 %), (25 %) respectively. Neuro-Behcet manifestations were present in (22.5 %) patient. Articular manifestations were present in (17.5 %) patients. Renal affection was present in (2.5 %). There were no GIT, cardiac or pulmonary involvement in studied patients
There is no significant statistical difference between males and females of BD patients as regard clinical manifestations
There were significant statistical differences between BD patients and control as regard total cholesterol, HDL-c, LDL-c, LDL\HDL ratio and TG.
There was significant statistical differences between BD patients and control as regard hemoglobin level but no significant difference as regard WBCs and PLT.
There were significant statistical differences between BD patients and control as regard ESR and CRP
There were no significant statistical differences between the BD patients and control as regard genotype and allele frequency of PON1. There was no significant difference in allele frequencies and clinical manifestations of BD
There was no significant statistical difference between PON1 genotypes as regard total cholesterol, TG, LDL-C and HDL-c.
There was no significant statistical correlation between lipid profile and BDCAF.
from this study, we concluded that PON1 L55M gene polymorphism is not associated with increased risk of BD or its clinical manifestations although there was increase in level of total cholesterol, LDL-c, TG and low HDL-c in patients with BD.
The principal limitations of this study were the small number of the studied patients and that paroxonase enzyme activity was not done.
Because of these limitations, we recommended that:
Further studies on large number of BD patients are to be done.
Assessment of PON1 activity in BD patients in association with PON1 gene polymorphisms.
Studying of lipid profile in BD patients with vascular manifestations and assessment of their atherosclerotic risk.