الفهرس 
EpidemiologyOnly 14 pages are availabe for public view
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Abstract
Introduction: Multiple sclerosis (MS) is an autoimmune demyelinating disorder. The etiology of MS remains unknown. Several environmental factors, including microbial agents, have been considered potential inducers of the disease. Amongst the microbial agents, Helicobacter pylori (Hp) has been considered a possible infectious trigger of the disease.
Aim of the work: to prove or disprove the relationship between infection by helicobacter pylori species containing hsp60 and triggering of multiple sclerosis.
Subjects and methods: A cross sectional observational and comparative study that recruited a group of sixty-five patients with multiple sclerosis from the outpatient multiple sclerosis clinic of Ain Shams University hospital, and a group of sixty-five age and sex matched healthy controls. Informed written consent was obtained from all the subjects.
Results: Patients with MS showed a higher level of anti Hp hsp60 IgG than control group and the level of this antibody was especially high at patients with SPMS.
Conclusion: possible relation between infection by Helicobacter pylori species containing this type of antigens and pathogenesis of MS in Egyptian population.