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Abstract Background: Arthroscopic knee surgeries are a painful surgical procedures requiring effective analgesia in the postoperative period to enhance functional recovery, and minimize postoperative morbidity. Peripheral block of the femoral nerve may be combined with other pain control measures for postoperative analgesia after arthroscopic knee surgeries. Aim of the Work: The aim of this study is to compare the effect of intra-articular magnesium sulfate with femoral nerve block versus intravenous magnesium sulfate with femoral nerve block for postoperative analgesia in patient undergoing arthroscopic knee surgeries under general anesthesia. Patients and Methods: This prospective randomized controlled trial (RCT) was done in orthopedic operating theatres at Ain Shams university hospitals, included 75 patients from both sexes aged 18 years or older, of American society of anesthesiology (ASA) physical status I&II and scheduled for arthroscopic knee surgeries under general anesthesia. These patients were randomly divided into 3 equal sized groups (each consisting of 25 patients). Results: Pain is significantly higher in control group at 6, 12, 24 hours at rest and movement compared to intra-arcticular and intravenous magnesium groups. VAS score was significantly lower in intra-articular group at rest and movement at 6, 12 and 24 hours postoperatively. Conclusion: compared to a single injection ultrasound guided femoral nerve block, the combined use of nerve block with intra-articular MgSO4 8%20ml or intravenous MgSO4 10% 30mg/kg in patients undergoing arthroscopic knee surgeries is associated with: significant improvement in the intensity of postoperative pain, extension of the duration of postoperative analgesia, and reduced postoperative analgesic requirements. The postoperative analgesic effects of intra-articular MgSO4 were superior to the intravenous route of administration. The least postoperative analgesic requirements were encountered with the use of the intra-articular regimen. |