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Abstract Some Staphylococcus species can cause a wide variety of diseases in humans and animals. Multi-drug resistant organisms including Staphylococcusspecies persist and spread worldwide Vancomycin has long been the preferred treatment of multi-drug resistant Staphylococci . <>Unfortunately vancomycin resistance has been reported in clinical isolates of Staphylococci Staphylococcus clinical isolates were collected, cultured, isolated and identified by several biochemical tests manually and automatically. Susceptibility tests for different antibiotics were performed by different methods. DNA of Staphylococcus isolates was extracted, and the presence of vanA gene was detected using PCR. The vanA gene sequence was determined. A total of 50 Staphylococcus isolates were isolated. They contain 13 Staphylococcus species . All isolates produced catalase, 18% produced coagulase. Many isolates were multi-drug resistant. 48 % of isolates had vanA gene. In conclusion the rules of infec tion control must be followed to avoid the spread of multi- drug resistant microbes. At the same time research has to focus on development of new antibiotics to treat the infected patients. Much work must be done to determine the true risk factors for infec tion and understanding the mechanisms of vancomycin resistance |