الفهرس 
INTRODUCTIONOnly 14 pages are availabe for public view
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Abstract
Unexplained infertility refers to the absence of a definable cause for a couple’s failure to achieve pregnancy after 12 months, or after 6 months in women with 35 years old of attempting conception despite a thorough evaluation, which includes assessment of Ovulation, Tubal patency, Normal uterine cavity, Normal semen analysis, Adequate ovarian oocyte reserve. Unexplained infertility does not mean there is no physical explanation for the infertility, but that is just, medical tests have not identified any specific problems.
Reproductive disorders concern approximately 25% of European and American couples; among the various causes of hypofertility, those of infectious origin have special interest, as in many cases infections can be treated successfully and the problem solved.
Helicobacter pylori infection affects approximately one half of the world population and it is more prevalent in developing countries. The clinical consequences of H. pylori infection are not limited to the gastroduodenal tract since many studies reported that it could contribute to cause extra digestive disorders and to play a role in the development of autoimmune diseases.
Recently, rising evidence has indicated a relationship between Helicobacter pylori infection and reduced fertility, in both men and women.
The aim of our study was to assess the correlation between Helicobacter pylori infection and unexplained infertility in Egyptian women.
The local Ethical Committee approved the study, and all cases signed a written informed consent for this research. It conducted at Elshatby university hospital, infertility clinic, university of Alexandria, during the period of January to June 2017. By the end of this study, data of 100 participants were statistical analyzed.
The present study was a cross section study, we recruited (100) women, (50) women per group. group I (Cases) included (50) cases with unexplained infertility. group II (Controls) included (50) fertile women. We used in our study The EUGENE® H. Pylori Ab Rapid Test as a detection kit for H. pylori infection. Serum and Cervical mucus samples from all women were assayed for H. pylori antibodies (IgG). It was found that 32 cases (64%) of unexplained infertility women group I were positive for H.pylori IgG in serum. As regards normal fertile control group II, we found that only 7 women (14%) were positive for H.pylori IgG in serum. So H.pylori IgG in serum was significantly higher in cases of unexplained infertility when compared to normal fertile control women with P-value (<0.001) showing that they are statistically significant. Finally, the result of H.pylori IgG in cervical mucus of unexplained infertility cases were 6 cases (12%) and (0.0%) of normal fertile control women with FEp (0.027) showing that they are statistically significant thus reinforcing the role of H. pylori infection in the pathogenesis of unexplained infertility.
lastly, the possibility that there is an association between Helicobacter pylori infection and reduced fertility, in both men and women remains and deserves further exploration, given that these bacteria can produce inflammatory response and toxins that may be implicated in the pathogenesis of the disease. In conclusion, our analysis showed a positive association between H. pylori infection and unexplained infertility in Egyptian women and further prospective studies are required to prove this hypothesis. and in particular to perform study dealing with evaluation of reproductive potential after eradication of H. pylori infection. Given the importance of this potential association, further verification is warranted.