الفهرس 
AbstractOnly 14 pages are availabe for public view
 |  | from | 83 |  |  |
| | | from | 83 | | |
Abstract
The present thesis describes preparation and investigation of the performance characteristics of new plastic membrane and carbon paste selective electrodes of the conventional polymer membrane types for the pharmaceutical compound: Oxomemazine hydrochloride (OMCL). The active entity is a plasticized polyvinyl chloride (PVC) membrane containing a dissolved ion-exchanger which is tetraphenylborate of Oxomemazine. The thesis comprises three chapters. .
from this study, it can be concluded that:
1- tetraphenylborate are promising candidates for formations of highly insoluble ion-associates with Oxomemazine, which can be used as ion- associate in PVC matrix or carbon paste selective for OM+.
2- Several plasticizers of different polarities were studied as solvent mediators for PVC electrodes. Sun flower oil, Corn oil as a low polarity solvent, provides more appropriate conditions for the incorporated of the drug cation to exchange with the soft ion-exchangers. Therefore, this solvent was used as the suitable plasticizer throughout the study.
3- Chemically modified carbon paste electrodes possess many advantages in comparison with polymeric membrane electrodes, namely, ease of preparation, ease of regeneration, very stable response and very low ohmic resistance.
4- The nature and amount of modifier and solvent mediator (plasticizer) significantly influence the sensitivity and selectivity of modified carbon paste electrode.
5- from the performance characteristics of the studied electrodes, it can be concluded that most of these electrodes have closely similar characteristics, namely the linear concentration range, working pH range, response time, life span etc.
6- The investigated electrodes were used in the determination of the drug in bulk, and pharmaceutical preparation.
Thus, it is clear that the proposed electrodes might be useful detectors and interesting alternatives for the determination of OM+ ions in different real samples. The present electrodes show high sensitivity, reasonable selectivity, fast static response, long-term stability and applicability over a wide pH range with minimal sample pretreatment. The reported methods of determination with the prescribed electrodes offer the advantages of simplicity, accuracy, automation feasibility and applicability to turbid and coloured sample solutions. The methods are advantageous over many of the previously published procedures for OM determination, since of the interference of the excipients, impurities degradiation products or other accompying drugs is nullified.