الفهرس 
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Abstract
Uncontrolled type I DM is usually complicated by many CVD. Potassium channel openers particularly Nicorandil, are frequently used in the management of primary CVD like angina, hypertension and myocardial ischaemia. This raised a question in this study that, could Nicorandil be used in the management of secondary CVD complicating DM? and Does the use of Nicorandil in the management of such complications will accompanied by improving or worsening of the glycemic state?. Therefore, this study was settled down to elaborate the role of Nicorandil in preventing some cardiovascular complications in experimentally-induced adult male type I diabetic rats.
In the experimental design of this study, 50 adult male albino rats were used and they were randomly divided into 5 equal groups, each of which containing 10 rats as follows:
1. group I (control group).
2. group II (vehicle-treated group): Each rat in this group was subjected to a single injection of 0.5 ml of the vehicles sodium citrate buffer solution (50mM, pH 4.5).
3. group III (Nicorandil group): Each rat in this group was administered daily with oral Nicorandil (15 mg/kg) for 8 weeks.
4. group IV (Diabetic group): In this group, experimental DM was induced by a single I.P injection of freshly prepared STZ solution (45mg/kg BW) in 10 mmol/l citrate buffer (50mM, pH 4.5).
Summary
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5. group V (Diabetic/Nicorandil-treated group): In this group, the rats were rendered diabetic as in group IV and were immediately administered daily with oral Nicorandil (15mg/kg) for 8 weeks.
At the end of the experiment (after 8 weeks), the rats were fasted overnight then SBP was measured by the rat tail technique after which blood samples were obtained. After that, the rats were decapitated by cervical dislocation and the hearts were isolated. Subsequently, the following parameters were measured:
1. The force of cardiac contractility and heart rate in isolated hearts via Langendorff Heart Perfusion Technique.
2. Fasting serum glucose.
3. Fasting serum insulin.
4. HbA1c %.
5. MDA in the cardiac tissue.
6. GPx in the cardiac tissue.
The results of this study revealed that in the diabetic group there was a statistical significant increase of the serum glucose, HbA1c %, SBP, and the cardiac tissue MDA together with a statistical significant decrease of serum insulin, force of cardiac contractility and heart rate of the isolated hearts and the cardiac tissue GPX.
Summary
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These bad sequel and drawbacks of diabetes were, to a great extent, prevented by concomitant administration of Nicorandil with the onset of induction of the diabetic state. Nicorandil led to a statistical significant increase of the force of cardiac contractility, heart rate and the cardiac tissue GPX, in addition to a statistical significant decrease of SBP and the cardiac tissue MDA. However, Nicorndil did not significantly affect the serum glucose, insulin and HbA1c % in the diabetic rats.