الفهرس 
IntroductionOnly 14 pages are availabe for public view
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Abstract
Stroke is defined as rapidly developing clinical symptoms and/or signs of focal or global loss of cerebral function, with no apparent cause other than vascular origin, with symptoms lasting more than 24 hours or leading to death
Accurate and prompt prediction of functional outcome, mortality, and complications in patients with ischemic stroke are essential for patients, families, and clinicians. In this context, rapidly measurable and reliable blood biomarkers may refine clinical decision-making. Several blood biomarkers have shown the potential to predict outcome after ischemic stroke. However, to be useful in clinical routine, blood biomarkers are expected to improve the prognostic accuracy of established clinical variables such as stroke severity and age.
The current study was carried to search for any correlation between Vitamin D in the first day of ischemic stroke and its clinical severity, radiological findings and also its predictive value of functional outcome and mortality in ischemic stroke patients.
It was conducted on 43 patients presenting with acute ischemic stroke attending Neurology Unit of both Neuropsychiatric department, Faculty of medicine, Minoufiya University and Mansoura international specialized hospital and 10 age and sex matched healthy controls. Patients were 22 females and 21 males. Controls were 6 males and 4 females
The included patents were subjected to: full history taking, general examination, complete neurological examination, laboratory work up (serum Vitamin D level in the first 24 hours, routine laboratory investigations for etiology of CVS). They were also subjected to radiological imaging using CT brain And / Or MRI brain.
The clinical severity of stroke was assessed with National institute of health, stroke scale at admission and the stroke was classified according OCSP and TOAST classification.
The severity of the stroke was assessed 3 months later using Modified Rankin the scale. Favorable outcome was defined as MRS (0-2) while unfavorable outcome was defined as MRS (3-6).
This study showed that Vitamin D level was lower in patient with severe ischemic stroke on admission. Its level was positively correlated with a score of NIHSS scale.
Also the level of Vitamin D positively correlated with stroke outcome and mortality. Its level was positively correlated with a score of MRS scale.
Vitamin D level decreases with increased size of cerebral infarction more than 3cm. Also it decreases in large vessel ischemic stroke and stroke of total anterior circulation.
Vitamin D may be considered reliable prognostic marker in stroke patients and early measurement of Vitamin D could provide
better prognostic information for patients with acute ischemic stroke.