الفهرس 
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Abstract
Thyroid hormone plays an important role on various aspects of metabolism, development and differentiation of cells. The thyroid gland secretes the thyroid hormones, thyroxine (T4) and the more biologically active form triiodothyronine (T3). The World Health Organization (WHO) estimates that about 2 billion people are iodine- deficient, based on urinary excretion data. Thyroid disease is being increasingly diagnosed with greater awareness and is one of the chronic non-communicable disease affecting women more though male population is not spared of the ailment. It is estimated that about 200 million people are at the risk of Iodine Deficiency Disease in our country.
It is known that overt hypothyroidism leads to an increase in plasma cholesterol levels. Most studies in sub clinical hypothyroidism show comparable but less pronounced associations. There remains a debate regarding extent to which cardio vascular events and lipid profile are affected by various degrees of thyroid dysfunction.
The aim of the study was to evaluate the relation between hypothyroidism and dyslipidaemia in non-diabetic patients.
This study was carried out on 50 hypothyroid non diabetic patients regularly co+ming for management & follow up at Endocrine & diabetic clinic in Menoufia University (group I) and 20 healthy persons as control group (group II).
Our results summarized that:
- The mean age in group I (patients group) was 44.62±4.57 years, while in control group was 41.8±6.86 years, on comparing the two groups it was
found that there was no significant difference between the two groups regarding age.
- The body mass index in patients was 28.59±4.35, while in control was 22.41±2.86, there was a significant increase in BMI in patients than the control group.
- The serum cholesterol in patients was 246.52±30.54, while in control was 191.6±30.85, there was a significant increase in serum cholesterol in patients than the control.
- Serum triglyceride inpatients was 194.38±81.93, while in control was 188.20±80.44, there was an increasing in serum triglyceride in patients but this increasing was insignificant.
- HDL cholesterol in patients was 40.55±6.29 and in control was 45.40±8.11; there was a significant decrease of HDL in patients than control.
- LDL cholesterol in patients was 198.22±51.78, while in control was 139.65±31.68, there was significant increase in LDL in patients than the control group.
- Non HDL cholesterol in patients was 153.17±29.24, and in control was 145.75±31.00, there was no significant difference between the two groups regarding non HDL cholesterol,
- LDL/HDL ratio in patients was 5.18±1.55, while in control was 3.16±0.98, there was a significant increase in LDL/HDL ratio in patients than the control.
- Regarding thyroid hormones, there was a significant increase of TSH in patients than the control, while there was a significant decrease of both free T3 and T4 in patients than the control group.
- There was no significant difference between the two groups regarding fasting blood glucose and 2 hour post prandial blood level.
- There was no significant difference between the two studied groups regarding blood picture.
- There was no significant difference between the two studied groups regarding kidney and liver function.
- There was a positive significant correlation between TSH and serum cholesterol, LDL cholesterol, non HDL cholesterol and LDL/HDL ratio; on the other hand there was a negative significant correlation between free T3 and T4 and serum cholesterol, LDL cholesterol, non HDL cholesterol and LDL/HDL ratio.
- There was a positive significant correlation between TSH and BMI, while there was a significant negative correlation between free T3 and T4 and BMI.
- There was a positive significant correlation between 2 hour PP and TSH, and there was a negative significant correlation between free T3 and T4 and 2 hour PP.
- There was no significant correlation between thyroid hormones and liver and kidney function.