الفهرس 
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Abstract
It aimed to evaluate the effect of thymoquinone loaded on gold nano-particles,as apossible chemo-therapeutic agent in induced oral cancer of hamester buccal pouch expermental model through the modulation of NF-kB.tHIS study was carried out on ninety male syrian golden hamesters,they were divided into 3 groups:GroupA:A1”negative control”weren,t receive any treatment and A2”positive control”left pouches were painted 3 times/week with DMBA for 14w.group B ”self-control” to ensure safety of the drugs,was injected intra-peritoneally(i.p.) with GNPs,TQ,and