الفهرس 
Anatomy and Histology of LungOnly 14 pages are availabe for public view
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Abstract
Introduction: Amiodarone is an antiarrhythmic agent. It has many adverse effects; the most serious one is amiodarone induced pulmonary toxicity (AIPT). Coenzyme Q10 is a lipid soluble antioxidant agent, so it may have a possible protective effect against amiodarone toxicity.Aim of the work: to demonstrate the effects of coenzyme Q10 on AIPT mainly on the bronchiolar tree and alveoli in both adult and senile rats. Material and Methods: Forty eight male albino rats, twenty four adult and twenty four senile, were used in the present study. Animals were divided into six groups. group I consisted of twelve adult control rats. group II consisted of twelve senile control rats. group III consisted of six adult rats that received 0.35 ml of amiodarone. group IV consisted of six senile rats that received 0.55 ml of amiodarone. group V consisted of six adult rats that received both amiodarone and coenzyme Q10. group VI consisted of six senile rats that received both drugs. Coenzyme Q10 was dissolved in olive oil and administered by gastric tube, while amiodarine ampoules were administered through intraperitoneal injection. Both drugs were administered once daily for two weeks. At the end of the experiment, animals were sacrificed; lungs were excised, processed and examined using light microscope, electron microscope, immunohistochemical studies and morphometric analysis. Results: Following administration of amiodarone to adult rats, there was marked distortion of the lung architecture which dramatically improved after treatment with both drugs. Also, the lung sections of senile male albino rats treated with amiodarone had markedly distorted architecture that was aggravated by senile changes and only partially improved after treatment with both drugs. Conclusion: Administration of amiodarone can induce severe lung damage in both adult and senile male albino rats. Coenzyme Q10 had a notable protective effect against AIPT in adult rats. However, the expectation of this combined therapeutic approach is not sufficient to protect against AIPT in elders.