الفهرس 
ALLERGYOnly 14 pages are availabe for public view
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Abstract
Allergy is a state of sensitization of the immune system, Programming of disease in fetal and early postnatal life has been hypothesized to be an important mechanism for atopic diseases, peripheral blood mononuclear cell responses to allergen can be detected from as early as 22 weeks gestation, Many immune cells, including neutrophil, monocytes, macrophages and lymphocytes, express Fas (CD95) on their surface.
We assessed soluble Fas Ligand as a marker of fetal programming and early predictor of feto-maternal aeroallergen sensitization in relation to in-vivo IgE assessment and peripheral blood mononuclear cells.
A total of 60 subjects were included, divided into 2 groups, group I included 30 newborn infants born to mothers with positive history of allergic diseases and /or positive SPTs to aeroallergens, group II included 30 newborn infants born to mothers with negative history of allergic diseases and negative SPTs to aeroallergens. Cord blood s.FAS ligand and CBC with differential leucocytic cell count was measured, Skin prick test was done to all mothers within the first 2 weeks after delivery, and to all newborns after 1 year.
20 infants from group I had positive skin prick tests, 4 from group II had positive results (P=0.000), The level of s.Fas ligand was significantly higher in the cord blood of the non allergic group (Median=389.3 range =112.70 – 949.8) when compared to the study group(Median= 261.1 Range =(149.2 – 406.7) (P=0.016), and in group I its level was higher in children with negative SPT results (P=0.068), percentage of MNCs in the allergic group was significantly higher than in the control group. (P= 0.025), the number of CBMNCs and their percentage were significantly higher in infants with positive SPT results in group I (P= 0.036 and 0.007 respectively).
Cord blood MNCs percentage was more specific (90.32 %) than MNCs number (74.19%) and cord blood sFas ligand as an early predictor of allergic diseases, S.Fas ligand is the least sensitive (75%) and specific (67.74 %) marker.