الفهرس 
IntroductionOnly 14 pages are availabe for public view
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Abstract
1- Scope of investigation:
This section outlines the objectives for the design, synthesis and biological evaluation of the target compounds (diacylhydrazines 8a-n, bis-hydrazonoyl chlorides 10a-h, diaryl oxadiazoles 9a-c and triaryltriazoles 12a,b) as anticancer agents.
2- Results and discussion:
This section is subdivided into four main sections:
A- Docking study of all target compounds: diacylhydrazines 8a-n, diaryloxadiazoles 9a-c, bis-hydrazonoyl chlorides 10a-h and triaryltriazoles 12a,b inside colchicine-binding site of tubulin. The results displayed strong H-bonding in case of diacylhydrazines 8a-n and bis-hydrazonoyl chlorides 10a-h.
B- Chemistry section: Chemistry section includes the following:
1) Different methods used in the chemical synthesis of diacylhydrazines 8a-n, diaryloxadiazoles 9a-c, bis-hydrazonoyl chlorides 10a-h and triaryltriazoles 12a,b
2) Identification of target compounds by different spectroscopic methods of analysis: 1H NMR, DEPT-Q 13C NMR and elemental analysis.
C- Biological evaluation of anticancer activity:
Results revealed that some of the tested compounds (8a, 8c-f, 8i,k , 8m, 9a, 9c, 10e and 12a,b) exhibited moderate to remarkable anticancer activity against most NCI-60 cell line panel especially NCI-H522.The results also showed that 10e have a promising activity in NCI screening which is comparable to the 2016 NCI data of colchicine reference compound against NCI-H522 cell line. The results showed a promising cancer cell growth inhibition of all the four derivatives 10e, 10g (isomer 1), 10g (isomer 2) and 10h. Geometrical isomerism in 10g remarkably affected the anticancer activity.
3- Experimental
This section outlines the detailed procedures of different experiments carried out, including the synthesis and identification of target compounds, also the procedures used to investigate the anticancer activities of some of the synthesized compounds, and finally the methodology and software used for the molecular modeling of target compounds.
4- Recommendations
Bis-hydrazonoyl chloride derivatives 10e, 10g (isomer 1), 10g (isomer 2), 10h are strongly recommended as antiproliferative agents in cancer therapy, probably acting by irreversible tubulin alkylation mechanism. Efforts should be exerted to prove this mechanism.