الفهرس 
ContentsOnly 14 pages are availabe for public view
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Abstract
The aim of the present work is to synthesize some of new heterocyclic compounds like quinazoline and benzotriazine and study their biological activity as antioxidant. The original work of the thesis is divided into three parts: Part I: Utilization of Isatoic Anhydride in the Synthesis of New Quinazoline Scaffolds as Antioxidant Agents Include efficient strategy for the synthesis of quinazoline derivative 4, 7, 10, 13 and 16 by the reaction of isatoic anhydride with different aromatic amine ( namly: 4-aminoacetophenone, 5-(4-aminophenylazo)-benzene-1,3-disulfonic acid, 4-aminohippuric acid and 2-aminobenzothiazole derivatives) to give anthranilamide derivative 3, 6, 9, 12 and 15, followed by condensation reaction of this anthranilamide with aromatic aldehyde (namely; p-tolualdehyde and p-anisaldehyde) to give the corresponding quinazoline derivative. These compounds were tested as antioxidants. Compounds that exhibited more than 60% inhibition of the ABTS radical cation were in the order of: ascorbic acid > 7 > 4b > 4a > 10.Part II: Synthesis of Some New Benzotriazine-based Heterocycles as Anticancer Agents The reaction of isatoic anhydride with cyanoacetic hydrazide was achieved to give benzohydrazide derivative 17 which treated with nitrous acid at low temperature to give benzotriazine derivative 30. The reactivity of compound 30 was investigated towards electrophilic coupling reaction with aryl diazonium chlorides to give componds 31. Condensation of starting material with various aromatic aldehydes in refluxing ethanol furnished compouds 32 which underwent refluxing with malononitrile in ethanol and drops of piperidine to produce compounds 34.