الفهرس 
INTRODUCTIONOnly 14 pages are availabe for public view
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Abstract
Breast cancer is the most common cancer in women. Breast conservation therapy (BCT) is the preferable treatment for women with early stage breast cancer. Overall survival of women undergoing BCT is equivalent to mastectomy. The goal of BCT is to completely excise the tumor with negative margins while maintaining acceptable cosmesis. Frozen section analysis (FS) and imprint cytology (IC) are the best methods for intraoperative evaluation of lumpectomy margins
This study was conducted on 40 female patients admitted to the Surgical Oncology Unit, Alexandria Main University Hospital, who were eligible for BCT. During the operation, the breast tumor was excised with 1 cm macroscopic margin, and surgical specimens were immediately marked with orienting sutures. Excised specimens of breast conservation surgery were sent to pathologist for both IC and FS to assess safety margins.
The study compared results of IC for the 259 margins with the results of paraffin section for the same number of margins. Sensitivity of IC was 91.35% and its specificity was 95%. The overall accuracy rate for this method was 94.21%. Sensitivity of FS was 96.91% and its specificity was 94%. The overall accuracy rate for this method was 94.59%.
Surgical treatment for early breast cancer is breast conservation therapy in the absence of its contraindications. It must be done in the presence of a good method of safety margin assessment to improve survival and prevent recurrence. Both frozen section and imprint cytology can be used safely to assess the margins intraoperatively. Sensitivity and specificity of both methods are excellent and almost equal.