الفهرس 
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Abstract
This study was carried out on sixty white male albino rats of 6 – 8 weeks old, weighted from 160 – 180 gm in faculty of Veterinary medicine – Mansoura University. Experimental rats were randomly divided into six groups, each group consisted of ten rats. group (1): it was kept as a control group in which rats were fed on an experimental ration without additives. group (2): rats were fed an experimental ration and received orally 0.6 mg Se/kgB.wt as sodium selenite at dose 1/20 of the oral LD50 of sodium selenite (12.7 mg/kg). group (3): rats were provided with an experimental ration and received 1.2 mg Se/kgB.wt at dose 1/10 of the oral LD50 of sodium selenite. group (4): rats were supplemented with an expermintal ration and received 0.6 mgSe/kgB.wt and injected with 0.5 mg/kgB.wt of adriamycin intravenously in tail vein twice weekly. group (5): rats were fed an expermintal ration and received 1.2 mgSe/kgB.wt and injected with 0.5 mg/kgB.wt of adriamycin intravenously in tail vein twice weekly. group (6): rats were supplemented with experimental ration and injected with 0.5 mg/kgB.wt of adriamycin intravenously in tail vein twice weekly. The experimental period continued for four weeks.The results of this study showed that the selenium concerning its biological effects have an important role particularly in relation to cardiovascular. The cardioprotective role of selenium as well as a strong antioxidant against adriamycin-induced cardiotoxicity is able to protect cardiac tissues from oxidative stress and damage by scavenging free radicals and inhibiting lipid peroxidation. GPx is selenocysteine dependent enzyme, and its activity is known to be dependent upon an adequate supply of dietary selenium which regulates gene expression of these selenoproteins. GPx-1 gene expression is increased with increasing selenium supplementation and decreased with lower selenium status, but it is decreased with an increase of the oxidative stress resulted from repeated administration of adriamycin which may be contributed to the development of cardiomyopathy and heart failure.In the light of this study, we recommended that supplementation of diet rich in the natural antioxidants such as selenium is extremely essential to protect the heart from cardic diseases induced by chemotherapeutic drugs as adriamycin. Moreover, Se could be used to protect cancer patients from adriamycin-induced cardiomyopathy.