الفهرس 
Abstract
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Abstract
Recent scientific research has been devoted to the development of rate controlled drug delivery systems. The sustained, modified or controlled drug delivery systems are dosage forms that designed to accomplish the purpose of better patient compliance, sustained drug release and delivery of drug at the site of action. The goal of this investigation was to study the sustained release solid dosage forms using two different floating drug delivery system approaches which are: single unit floating dosage system (non-effervescent), and floating microspheres. To fulfill these goals, this thesis comprises the following two parts: The first part deals with the formulation and evaluation of diltiazem hydrochloride floating tablets.The second part deals with the preparation and characterization of atenolol microspheres sustained release tablets. This thesis consists of two parts:Part I: The goal of work in this part was to formulate the sustained- release floating tablets of diltiazem hydrochloride. The prepared tablets were assessed for their physicochemical characters, buoyancy behavior, swelling ability and in-vitro drug release pattern. Also, the stability study for the optimized formulations was investigated. Finally, the bioavailability of the drug from the optimized formula, on the basis of good physicochemical properties, acceptable sustained release profiles and stability results was studied.Part II: The main goal for the study in this part is to prepare sustained release floating tablets of atenolol (AT). Ethyl cellulose (EC) floating microsphere loaded with AT was prepared. The prepared microspheres were characterized for their physicochemical characters and in-vitro drug release pattern. The floating tablets containing microspheres loaded with AT were prepared. The prepared tablets were assessed for their physicochemical characters and in-vitro drug release pattern. In addition, tracing of the selected floating tablet in GIT (gastrointestinal tract) using X-ray, was a matter of interest to be evaluated in such investigation, in order to determine the exact tablet position in GIT after oral administration. The thesis comprises two main parts including 162 pages, 218 references, 31 figures and ends with Arabic summery.