الفهرس 
Vitamin D Physiology and StructureOnly 14 pages are availabe for public view
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Abstract
Effect of Vitamin D Supplementation on Patients with Graves disease
Nermin A. Sheriba , Abeer A. Abdalla , Maram M. Mahdy , Ahmed Bahaa , Nesma Aly , Dina Marawan
Abstract :
Background: Graves disease (GD) is an autoimmune disease characterized by hyperthyroidism secondary to circulating auto-antibodies. It has become apparent that multiple factors contribute to the etiology of (GD), including genetic and environmental factors.The role of vitamin D is well known in calcium metabolism and skeletal homeostasis. Vitamin D has also been shown to be a modulator in both innate and adaptive immunity .There is a well-established link between vitamin D deficiency and various autoimmune diseases,including type 1 diabetes mellitus,systemic lupus erythematosus, rheumatoid arthritis,inflammatory bowel disease, and multiple sclerosis.The prevalence of vitamin D deficiency was reported to be common in patients with GD.Interestingly,vitamin D deficiency is found to be associated with higher thyroid volume in patients with newly onset GD.Whether vitamin D deficiency has a causal relationship with GD remains a controversial issue.Objective:to evaluate the effect of vitamin D supplementation in patients with GD with and without opthalmopathy Subjects and methods:A randomized prospective study was conducted on 60 adult patients with Graves’ disease aged (20-40) yearsgroup 1: 20 patients with Graves’ receiving daily dose of 30mg of methimazole alone.group 2: 40 patients with Graves’ receiving same dose of methimazole supplemented with vitamin D3 200.000IU/month for 3 months.Patients were followed up over (3months duration).Results: 40% of patients in group 1 and 72.5% in group 2 were vitamin D deficient,Vitamin D was significantly correlated with thyroid volume and degree of exophthalmos .On Vitamin D supplemention,group 2 had significant lower thyroid volume and better effect on the degree of exopthalomos.Conclusion:Vitamin D suuplementation for GD has a favourable effect on thyroid volume and on the degree of exophthalmos
.Key words: GD, Exophthalmos, Vitamin D