الفهرس 
Metabolic SyndromeOnly 14 pages are availabe for public view
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Abstract
Background: There is increasing concern that sugar consumption may be linked to the development of metabolic syndrome and cardiovascular and kidney diseases.
Aim of work: The purpose of the present study was to investigate vascular and renal dysfunction in female rats of different age groups (young, adult and old) with metabolic syndrome and to evaluate the impact of age on this dysfunction.
Materials and methods: The study was performed on adult female albino rats, divided into 6 groups: Young female control rats, Young female rats with metabolic syndrome, Adult female control rats, Adult female rats with metabolic syndrome, Aged female control rats, Aged female rats with metabolic syndrome.
Metabolic syndrome was induced by 61% fructose -containing diet for 8 weeks.
All rats were subjected estimation of: Body weight and calculation of body mass index and lee index, Visceral fat, liver and kidney weight, Isolated aortic ring vascular reactivity study, Fasting blood glucose level, Plasma insulin level, The calculation of homeostasis model assessment of insulin resistance (HOMA-IR), Plasma Lipid profile, C- reactive protein, Determination of a marker of oxidative stress malondialdehyde (MDA) and total antioxidant capacity (TAC), Plasma creatinine, Study of the aorta for its content of Nitrite. Histopathological study of rats, aorta, kidneys and liver.
Results: establishment of metabolic syndrome was ensured by high levels of triglycerids, blood glucose level and significant increase in body mass index. All metabolic syndrome rat groups exhibited significant increase in their vasoconstrictor response to KCL. The increase in vasoconstrictor response to PE was significant in young and adult groups only and was found to be significantly increased in the young metabolic syndrome rat group compared to the old group. The A.ch –induced vasodilatation was not significantly changed in all metabolic syndrome rat groups compared to control groups. NO content of aortic rings of metabolic syndrome rat groups was significantly decreased when compared to their respective control groups. All metabolic syndrome rat groups showed significant increase in plasma levels of C-reactive protein, MDA, and creatinine as well as significant decrease in TAC compared to their respective control rat groups. Histopathological study revealed that aortic rings of all metabolic syndrome rat groups had increased wall and intimal thickness, smooth cell hyperplasia, excess collagen, thin fragmented elastic fibers particularly in the old metabolic syndrome rat group. The kidneys of all metabolic syndrome rat groups showed shrinkage of the glomeruli and cell necrosis, thickened basement membrane, loss of pseudopodia. The liver tissue in metabolic syndrome at groups showed fat accumulation. Inflammatory cellular infiltration was also seen in the aortic rings, kidneys and livers of metabolic syndrome rat groups.
Conclosion: The result of this study showed the adverse effect of chronic consumption of high fructose diet and might spur health care professionals to direct their efforts to raise the community awareness of the health hazards of high fructose –induced metabolic syndrome and its association with vascular and renal changes. It might be recommended that children, adolescentsand young adults female be the focus of this awareness because the study revealed that young and adult groups were affected. Also, investigating dietary and life style interventions to limit the progress of metabolic syndrome and its impending complications might be helpful.