الفهرس 
IntroductionOnly 14 pages are availabe for public view
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Abstract
ALL results from an acquired or a genetic injury to the DNA of a single
cell in the marrow. The effects of ALL include uncontrolled and exaggerated
growth and accumulation of cells called “lymphoblasts” or “leukemic blasts,”
which fail to function as normal blood cells.
The presence of the leukemic blasts blocks the production of normal
cells. As a result, when ALL is diagnosed, the number of healthy blood cells
(red blood cells, white blood cells and platelets) is usually lower than normal.
It has been shown that miRNAs may regulate DNA methylation and
control the expression of histone deacetylases and histone methyltransferases
for example mirna 502 that regulate SET8 gene by the sequence-specific
binding to target mRNA . But the binding affinity may be affected by SNPs
residing in miRNA target sites, which may in turn affect the miRNAs’ ability
to inhibit the mRNA translation into proteins or lead to degradation of the
mRNA .
Indeed, many studies have demonstrated that SNPs at miRNA-binding
sites are likely to affect expression of the miRNA target genes and thus may
contribute to susceptibility to cancer. Many studies have also shown that
SNPs at miRNA-binding sites play a role as novel biomarkers for cancer risk.