الفهرس 
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Abstract
Nowadays, TNBC is one of the most attractive areas of research.
Reasons for this scientific interest are the lack of a recognized target for
molecular-oriented therapy, which makes TNBC a new orphan disease;
therefore it represents an important clinical challenge because these
cancers do not respond to endocrine therapy or other available targeted
agents.
Considering the gene-expression analysis, it appears very clear that
TNBC is a heterogeneous BC form, which shows only partial overlapping
features with so-called basal-like (BL) breast cancer. Triple negative
phenotype characterized by distinct clinical, histopathological and
molecular characteristics, and was associated with the development of
recurrence and distant metastases, and a poorer prognosis.
Better understanding of the imaging features of TN cancers
especially at MRI, provides an imaging biomarker with clinical
implications.
This study aimed to determine the dynamic contrast-enhanced
magnetic resonance imaging features of TN breast cancers in comparison
to other breast cancer subtypes and to evaluate the DCE-MRI impact on
management of such cases, especially in detection of response after NAC.
Summary and conclusion
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In conclusion, in this study; TNBC presented several MRI features
on DCE-MRI such as multiple lesions, mass enhancing type, irregular
shape, not circumscribed margin, rim enhancement, high T2 signal
intensity and malignant kinetic curve pattern.
Also this study demonstrates certain MRI features with significant
differences that are more frequent with Triple negative breast cancer
compared with other breast cancer subtypes such as round shape mass
lesion, mass with rim enhancement in post contrast images and
intratumoral bright signal intensity on T2 weighted images.
While other DCE-MRI parameters show no statistically differences
between TN and non-TN breast cancer, which are distribution of FGT
and BPE, mass margin, non mass enhancement distribution and
enhancement pattern, lymph nodes status and types of kinetic curves.
Post neoadjuvant chemotherapy MRI assessment is a valuable tool
to detect response which affected the management of breast cancer cases
especially triple negative BC.