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العنوان
Effect of Cocoa and its Extracts on Hypercholesterolemic Rats /
المؤلف
Rashed, Faten Kamal Ahmed Abdalla.
هيئة الاعداد
باحث / فاتن كمال احمد عبد الله راشد
مشرف / خالد علي عبد ارحمن شاهين
مناقش / عبد الغني محمود عبد الغني
مناقش / هبه عز الدين يوسف
الموضوع
nutrition.
تاريخ النشر
2017.
عدد الصفحات
88 p. :
اللغة
الإنجليزية
الدرجة
ماجستير
التخصص
اقتصاد منزلي
تاريخ الإجازة
7/5/2017
مكان الإجازة
جامعة المنوفية - كلية الإقتصاد المنزلى - التغذية وعلوم الاطعمة
الفهرس
Only 14 pages are availabe for public view

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Abstract

Cocoa is one of the nutrients that are used widely in the food industry. cocoa beans is containing flavonoids such as albrosianaedin, catechins and epicachen it serves as antioxidants help protect the body from free radical it also helps decrease cholesterol that helps to protect the heart and blood vessels. The aim of this study was to evaluate the effect of cocoa powder and its water and ethanol extracts on blood lipids and the antioxidant status of high blood cholesterol. forty-eight adult white mice were randomly divided into two main groups. group 1: The control group (6 mice) was fed on the standard diet only throughout the trial period. group II: The group of mice with high blood cholesterol (42 rat) were fed on the standard diet plus cholesterol for 21 days and then divided randomly to 7 equal sub groups .The first positive control group rats fed basal diet, the second and third groups rats fed basal diet plus 2.5 and 5 g / kg body weight /day of cocoa powder as a water extract respectively, by stomach tube. the fourth and fifth groups rats fed basal diet plus 2.5 and 5 g / Kg body weight/day of cocoa powder as an ethanol extract, respectively, by stomach tube. The sixth and seventh groups rats fed basal diet plus 2.5 and 5 g / kg body weight/day of cocoa powder, respectively. At the end of the trial (30 days), eating rats high cholesterol diets led to an increase in the level of cholesterol, triglyceride, low density lipoprotein, very low density lipoprotein, alanine amino transferase and aspartate aminotransferase in the positive control group. There was also a decrease in the level of high-density lipoprotein, catalase and glutathione trans-ferase in the positive control group. The results showed that the highest improvement in blood lipids was observed in the high blood cholesterol groups, which were fed on the concentration of 5 g / kg body weight of water and ethanol extract and cocoa powder Compared to the negative control group. The results of the study showed that there was a significant increase in the activity of glutathione transferase (GTF) and catalas CAT) after eating the rats 2.5 and 5 g / kg body weight of the water and ethanol extract and cocoa powder compared to the positive control group while the malonaldehyde was in the opposite trend. The study found that eating cocoa powder, water and ethanol extract resulted in lower cholesterol level, improved liver and kidney functions, and increased antioxidant enzymes.