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Abstract bile duct and canaliculi and (22.2%) in Canaliculi only, while absent visible bile plugs was found only in those with failed Kasai (8.7%) (P <0.05). There was significant statistical difference between patients with successful vs. failed Kasai as regards preoperative anti-muscle actin expression in portal tracts and at the interface in liver tissues, where all patients with successful Kasai (No=9 100%) had negative staining/or very rare cells with positive anti-muscle actin expression (P <0.05). Most of patients with successful Kasai had significant negative staining of VEGF in (AWs; 66.7%, BDs; 55.6% and hepatocytes; 55.6%) while most of those with failed Kasai had positive staining of VEGF in (AWs; 91.3%, BDs; 91.3% and hepatocytes; 86.9%) (P <0.05). Of the most frequent cases of non-BA group were PFIC-III (17 of total 38), followed by CMV (6 cases), INH (4 cases) and cholangitic type of CHF (2 cases). These cases were the most misdiagnoses with BA patients who had positive VEGF in portal structures and hepatocytes (PFIC-III: 3/6), (PFIC-I: 1/6), (cholangitic type of CHF: 1/2) and in hepatocytes (PFIC-I: 1/6), (PFIC-II: 1/5), (PFIC-III: 1/6), and (CMV: 2/6). So these findings may refer to the relation between angiogenesis and fibrogenesis should be considered in cholestatic diseases other than BA, which had the most common misdiagnoses with BA and open a new way for their management. In |