الفهرس 
ACUTE MYELOID LEUKEMIA
Genetic ClassificationOnly 14 pages are availabe for public view
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Abstract
Acute myeloid leukemia (AML) is a genetically heterogeneous
clonal disorder characterized by the accumulation of acquired genetic
alterations in the hematopoietic progenitor cells. These alterations disturb
normal mechanisms of cell growth, proliferation and differentiation
resulting in the accumulation of leukemic cells in the bone marrow,
ultimately replacing most of the normal hematopoietic cells and their
functions, resulting in signs and symptoms of the disease. These include,
most prominently, anemia, hemorrhage, infection and their
consequences.
Classification of AML has tradionally based on combination of
morphology and cytochemical staining. The introduction of
immunophenotyping and cytogentic added important laboratory tools for
diagnosis, classification, in addition to predicting prognosis.
AML Diagnosis begins with a medical history, physical
examination, complete blood count, and blood smears. Blast cells are
seen on blood smear in majority of cases. A bone marrow examination is
conclusive proof of AML.
NRP-1 is multifunctional transmembrane protein that play an
important role in development, immunity and cancer. It is coreceptor that
enhances response to several growth factors and other mediators under
physiological and pathological conditions.
There an evidence that bone marrow cells are recruited to the sites
of neoangiogenesis through NRP-1 receptor and they are essential for the
maturation of the activated endothelium and formation of arteries. The.