الفهرس 
Epidemiology And EtiologyOnly 14 pages are availabe for public view
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Abstract
Retrospective Study Of Survival Benefit Of Second Line Chemotherapy In Adult Soft Tissue Sarcomas
Waleed Abdel Moneim Biome; Dr. Amr Shafik Tawfik; Dr. Doaa Atef Mohamed; Mustafa Ibrahim Abbas Abdel Gawad Faculty of Medicine, Ain Shams University
Soft tissue sarcomas (STS) are relatively rare heterogeneous group of mesenchymal neoplasms that may arise in soft tissue, skin or various organs, and show a broad range of differentiation, such as smooth muscle (leiomyosarcoma), adipocyte (liposarcoma), striated muscle (rhabdomyosarcoma), endothelium (angiosarcoma) or fibroblast (e.g., dermatofibrosarcoma). The aim of the work is to evaluate soft tissue sarcoma patients at Ain Shams University Clinical Oncology Department and Agoza Police Hospital in the last five years (2011-2015) as regards incidence, site, pathological types, response to second line chemotherapy and toxicity, progression free survival and overall survival. This is a retrospective study of patients with STS of different cell types and various sites of origin represented at Ain Shams University Clinical Oncology Department and Agoza Police Hospital in the last five years (2011-2015)Inclusion criteria Age ≥ 18 years.; Pathologically proven STS.; Radiological or clinical proven metastasis; Patient progressed on first line metastatic chemotherapy. Exclusion criteria: Patients with, Dermatofibrosarcoma protuberans; Kaposi’s sarcoma; Gastrointestinal stromal tumors; Desmoids tumors (aggressive fibromatosis); Co-morbidities interfering or contraindicated with appropriate chemotherapy regimens. This is retrospective study included 34 patients with soft tissue sarcoma (STS). The mean age of the patients was 40.9±13.4 years, ranging from 19 to 64 years with male predominance67%. There was an obvious histological diversity where synovial sarcoma was the most frequent type (29.4%) followed by liposarcoma and spindle cell sarcoma. Higher tumor grade was more common (59%) and distant metastases was detected in 18 patients (53%); more commonly with grade 3disease. Surgical treatment was adopted in 29 patients including only 2 amputations. Surgical margin was positive in 18/29 patients (62.1%). Palliative radiotherapy was used in 15 patients (44.1%). The most commonly used 1st line chemotherapy protocol was Ifosfamide + Adriamycin. Response after surgery and 1st line CTH was complete or partial remission in only 50% cases. Remission rate was apparently higher in patients with negative margin.