الفهرس 
Juvenile Idiopathic ArthritisOnly 14 pages are availabe for public view
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Abstract
Abstract
Background: Juvenile Idiopathic Arthritis is the most frequent chronic rheumatic disease in childhood. MAS is a complication of JIA with elevated morbidity and mortality. Aim of the Work: The aim of this study is to investigate the presence of MAS among juvenile idiopathic arthritis patients to assess the extent of the problem in those patients. Patients and Methods: This study includes: One hundred patients registered in pediatric departments and outpatient clinic of Physical Medicine Ain Shams University Hospital over the previous 2 years diagnosed as juvenile idiopathic arthritis (JIA) according to international league Against Rheumatism (ILAR) criteria which divides it into seven categories; systemic, oligoarthritis, polyarthritis rheumatoid factor [(RF) positive)], polyarthritis (RF negative), psoriatic, enthesitis-related and idiopathic juvenile arthritis. Results: Among the 100 JIA patients, 14 patients fulfilled the criteria and were diagnosed as MAS patients according to the preliminary diagnostic guidelines for MAS complicating JIA (Manoj et al., 2015) (figure 3). Two patients with MAS died. They represents 2% of all JIA patients and 14% of JIA cases with MAS syndrome. Conclusion: We can conclude from these results that macrophage activation syndrome is a potentially fulminant disorder whose incidence has increased more than before due to raised manifestations awareness. Recommendations: MAS is ignorable complication of any JIA patients; so its suspicion and detection must be considered in those patients, especially in the patients showing unexplained deterioration in their laboratory data and clinical condition.
Key words: systemic juvenile idiopathic arthritis, international league against rheumatism (ILAR), MAS